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Medical details have shown that co-administration with saquinavir or erythromycin improved plasma amounts of sildenafil by about three fold [see DRUG INTERACTIONS and Medical PHARMACOLOGY].The AUC on the active metabolite, N-desmethyl sildenafil, was improved 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These e

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